All lanes are back open on I-69 near the 314 mile marker, south of the Dupont Road exit.
AAA estimates 41.9 million travelers will go at least 50 miles to celebrate the holiday.
Police believe the driver of a Honda SUV may have had some sort of health problem that caused him to lose control and crash into the backyard of a home Monday morning.
A car and a truck collided Friday afternoon, prompting northbound lanes near Covington Road to be shut down. They have since been opened.
The deadly crash took place on Easter weekend in Wells County. Anthony Dager pleaded guilty to three felonies earlier this week.
Police believe more than 15 people were involved; the exact number is still being determined because multiple groups were taken to local hospitals.
A woman was killed after a motorcycle driven by an off-duty officer crashed in downtown Indianapolis early Friday morning.
The bicyclist apparently rode into the path of the SUV at the intersection of Homestead and Covington at around 2 p.m. Thursday.
A driver accelerated to more than 70 mph on a residential street in Detroit while fleeing officers before striking and killing two young children and injuring three other children and an adult, police said.
No one was hurt in a crash that left a car upside down on its roof.
Investigators are trying to figure out how the person managed to get hit on a set of tracks in the northwest part of Fort Wayne.
The crash took place on U.S. 6 at the I-69 overpass in DeKalb County. Both drivers were treated at the scene.