State police say about 70 passengers were on the bus and the uninjured were taken to a nearby middle school.
The chase began on U.S. 30 in Fort Wayne and ended after police lost sight of the car which at that point was traveling the wrong way on I-69.
The driver apparently took a curve too fast at about 2:30 and the load shifted, causing it to come loose.
The accident took place Wednesday morning and disrupted downtown traffic for a while.
The Indiana Department of Transportation announced Tuesday two plows will be used on I-469 and U.S. 24 northeast of Fort Wayne.
Police say rainy conditions and fog were to blame for a driver going through a stop sign early Tuesday morning.
The 42-year-old Fort Wayne man was struck and killed early Tuesday morning on East State Boulevard. The driver has not yet been located.
Peggy A. Page, 37, of Pierceton is in critical condition after crashing into a vehicle on State Road 13 around 2:45 p.m. Monday.
The two-vehicle crash happened just before 5:00 p.m. Saturday in Whitley County.
Gert Ferenczy, 84, of Halifax Nova Scotia, Canada was critically injured in a crash in DeKalb County Saturday morning.
The driver, Jody Compton, was traveling on SR 8, east of CR 3 near Garrett, Indiana Friday night.
Indiana State Police say two drivers lost control of their vehicles after hitting ice on the bridge over West Jefferson Boulevard.