The driver was fleeing a previous crash where her Pontiac lost a tire and was seen weaving in and out of traffic from Fort Wayne to Ashley.
Investigators said speed and alcohol might have been factors in the crash.
The accident took place on State Road 101 in DeKalb County on Wednesday morning.
Police said criminal charges against the driver are possible, pending the results of a blood test.
The truck collided with a semi on the interstate early Thursday morning, causing traffic to be backed up for about 45 minutes.
The crash on I-469 Friday involved two semis and a minivan, forcing a section of the highway to be closed during the investigation.
The crash was reported shortly after 3 p.m.
The crash took place between the Maplecrest Road and Maysville Road interchanges. Traffic was restricted for several hours. All lanes were opened around 3:30 p.m.
The crash happened in the northbound lanes of the interstate between Maplecrest Road and I-69 just after 2:30 a.m.
Engle Road was closed for about six hours due to damage to a utility pole and power lines.
The car caught fire after first hitting several trees and then colliding into the utility pole.
The driver was taken to the hospital in serious condition.
The crash happened just south of the St. Marys River, near downtown Fort Wayne.
At least four vehicles were involved in the crash near Stellhorn and Reed roads.
Police say the SUV, which crashed in western Michigan, was “almost destroyed beyond recognition.”
The incident took place on a road in DeKalb County early Friday evening. A passenger in the van that crashed was hospitalized and police believe the driver, who was also treated for injuries may have been drinking.
The highway was closed just south of Wolf Lake for roughly 30 minutes.
Because of lane restrictions on Clinton, traffic could get congested on several road before and after the Trans Siberian Orchestra performance.
Just before 4 p.m. Monday, police and medics responded a crash at the 25 milemarker and another near the 26 milemarker.
State police believe the driver may have fallen asleep when she ran off the highway Sunday evening and hit a guardrail.