FILE - In this Feb. 1, 1982 file photo, host David Letterman, right, and guest Bill Murray appear at the taping of the debut of "Late Night with David Letterman" in New York. Murray's 44th and final appearance Tuesday, May 19, 2015, will mark the end of late-night television's most unique and enduring host-guest relationships. After 33 years in late night and 22 years hosting CBS' "Late Show," Letterman will retire on May 20. (AP Photo/Nancy Kaye, File)

David Letterman to sign off as late-night host

The transplanted Hoosier, who made Top Ten lists and ironic humor staples of television comedy and influenced a generation of performers, is hosting his final episode of CBS’ “Late Show” on Wednesday.