Rams linebacker Alec Ogletree celebrated the win with a Gatorade shower for McVay on the sideline in the final minutes.
Los Angeles’ defense also excelled against fill-in Colts quarterback Scott Tolzien. Trumaine Johnson intercepted Tolzien’s first pass and returned it 39 yards for a touchdown, while Lamarcus Joyner returned another pick 29 yards for another score in the third quarter.
Tolzien passed for 128 yards in his fourth career NFL start in place of Andrew Luck, who wasn’t ready to return from a right shoulder injury.
ndianapolis also played without center Ryan Kelly and top cornerback Vontae Davis, and the Rams thoroughly exploited every absence with an aggressive, exciting performance for a team that finished last season with 11 losses in 12 games.
Goff went 0-7 as a starter last year, but the No. 1 pick in the 2016 draft looked much sharper after an offseason of study under the 31-year-old McVay. Goff went 21 for 29.
The Rams produced their highest-scoring performance since November 2014 in their first game since McVay took over a franchise that went 4-12 in its 13th straight non-winning season and 12th straight non-playoff season.
Rookie Cooper Kupp’s first NFL touchdown catch put the Rams up 24-3 in the second quarter. That’s a bigger lead than the Rams held at any point over the past two seasons in St. Louis and Los Angeles, when they had the NFL’s worst offense.