According to police, the driver of the pickup was heading south on State Road 1 towards Bluffton when he ran a red light at the intersection with US 224. He crashed into the trailer of the semi that was heading west on US 224, which spun the pickup around before it ended up in the parking lot of a nearby business.
The pickup driver, whose identity has not yet been released, had to be cut from the vehicle. He was taken to an area hospital in critical condition.
The driver of the semi was not injured.